Phytochemical investigation and antidiabetic activity of Leaf extracts of Dalbergia sissoo (Roxb.) in alloxan induced diabetic rats

Diabetes mellitus is the most common endocrine disorder. The World Health Organization recommends the use of traditional and plant based medicines for the management of diabetes mellitus. The recommendation made by WHO on diabetes mellitus, investigation on hypoglycemic agents from medicinal plants have become more important The tribes are from villages in the koraput district located in the state of Odisha, India. In this districts, villagers consume decoctions from the leaves of these plants early in the morning for the treatment of ailments like. sore throats, heart problems, dysentery, syphilis, and gonorrhea. In the present investigation we have screened the ethanol ,ethyl acetate,n-butanol and pet.ether extracts of the leaves of the plant for antidiabetic activity in alloxan induced Diabetic rats. The extracts produced a significant antidiabetic effect on first, third, fifth and seventh days at 300 mg/Kg body weight.Among all the extracts of Dalbergia sissoo, ethanol extract of leaves exhibited highly significant antidiabetic activity are comparable with the standard drug (Glibenclamide). The observation values are reported as mean±SEM of each obserevations. The significance of difference among the various treated groups and control group were analysed by means of one way ANOVA followed by Dunnet’s ttest.The value of less then 5% (p < 0.05) was considered statistically significant.